anguish
an·guish
/ˈæŋgwıʃ/ noun [ noncount ]
: extreme suffering, grief, or pain
tears/cries of anguish
He experienced the anguish of divorce after 10 years of marriage.
mental anguish
They watched in anguish as fire spread through the house.
an·guished /ˈæŋgwıʃt/ adj [more ~; most ~]
She looked at me with an anguished expression.
I will never forget their anguished cries.