affliction
af·flic·tion
/əˈflıkʃən/ noun , pl -tions
formal
1 [ count ] : something (such as a disease) that causes pain or suffering
She lost her sight and is now learning to live with her/the affliction.
He died from a mysterious affliction.
2 [ noncount ] : the state of being affected by something that causes suffering
her affliction with polio