I prefer the "design for available browser area" approach, because you shouldn't force the user to maximize his browser window to fully view your website even though there would be a CSS for smaller browser areas (but you don't use it because the user THEORETICALLY has more screen space). This not only affects desktop users with widescreen monitors but also tablet users. E.g. Windows 8 will bring a convenient function to scale the browser to 2/3 of the screen width, which might be too small for your website to display properly.
I would always design for the available browser area. The mobiel device market and also hardware manufacturing ( higher screen resolutions and screen ratios) is constantly evolving and trust me designing for a device will put your website in a mess in a short period of time.
Let me know what your final decision will be as I am really interested in this subject.
I am leaning towards a mobile first approach or rather a minimal non device specific one. Small style sheet and the site built for mobile first then adding things in for the higher resolutions via media queries.
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我更喜欢“设计可用浏览器区域”的方法，因为你不应该强迫用户最大化他的浏览器窗口以完全查看你的网站，即使有一个用于较小浏览器区域的CSS（但你不使用它，因为理论上用户拥有更多的屏幕空间）。
这不仅会影响使用宽屏显示器的桌面用户，还会影响平板电脑用户。例如，Windows 8将带来一个方便的功能，可以将浏览器缩放到屏幕宽度的2/3，这可能太小而导致您的网站无法正常显示。
I prefer the "design for available browser area" approach, because you shouldn't force the user to maximize his browser window to fully view your website even though there would be a CSS for smaller browser areas (but you don't use it because the user THEORETICALLY has more screen space).
This not only affects desktop users with widescreen monitors but also tablet users. E.g. Windows 8 will bring a convenient function to scale the browser to 2/3 of the screen width, which might be too small for your website to display properly.
我总是会针对可用的浏览器区域进行设计。移动设备市场和硬件制造（更高的屏幕分辨率和屏幕比例）正在不断发展，相信我，为设备设计会在短时间内让您的网站陷入混乱。
让我知道您的最终决定是什么，因为我对这个主题非常感兴趣。
I would always design for the available browser area. The mobiel device market and also hardware manufacturing ( higher screen resolutions and screen ratios) is constantly evolving and trust me designing for a device will put your website in a mess in a short period of time.
Let me know what your final decision will be as I am really interested in this subject.
我倾向于移动优先方法，或者更确切地说是最小的非特定于设备的方法。小样式表和网站首先为移动设备构建，然后通过媒体查询添加内容以获得更高分辨率。
I am leaning towards a mobile first approach or rather a minimal non device specific one. Small style sheet and the site built for mobile first then adding things in for the higher resolutions via media queries.