The content is the most important thing (not the UI). The next most important thing is to use good semantic HTML - use headings H1-H6 wisely to indicate the structure of your content, use lists when appropriate.
The second most important thing is to write good alt text for images. Use short, descriptive text to describe the function of the image ("warning", or "brick house"). If you specifically don't want an image to be read out, because it is purely decorative, set the alt text to an empty string rather than leaving it out.
Finally, if you want to style your site to make it look pretty, do this using CSS - the screen reader will ignore the CSS, but the site will be more credible if it looks nice - even if blind people are the primary audience.
Finally, if blind people are the primary audience for your site, then consider not using Ajax - while screen readers do cope with Ajax to varying degrees, a site with full page refreshes is much easier to use.
There are many other sites on "web accessibility" but this is the core foundation.
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网页内容无障碍指南 (WCAG) 概述
电子和信息技术无障碍标准（第 508 节）
HTML5 对辅助功能提供了哪些改进？
Web Content Accessibility Guidelines (WCAG) Overview
Electronic and Information Technology Accessibility Standards (Section 508)
What improvements to accessibility are offered by HTML5?
如果您不做其他事情，请记住三件事：
最后，如果盲人是您网站的主要受众，那么请考虑不使用 Ajax - 虽然屏幕阅读器确实在不同程度上处理 Ajax，但全页面刷新的网站更容易使用。
还有许多其他网站介绍“网络可访问性”，但这是核心基础。
If you do nothing else, remember three things:
Finally, if blind people are the primary audience for your site, then consider not using Ajax - while screen readers do cope with Ajax to varying degrees, a site with full page refreshes is much easier to use.
There are many other sites on "web accessibility" but this is the core foundation.