You can reject your first binary and upload the new one. Your position in the review queue will be reset. If you are worried about the release date more than your stability fixes you can just submit the update immediately after it is released to the app store.
Changing the Status of Your App - “Developer Rejected” and “Developer Removed From Sale”
Once you have submitted your binary, iTunes Connect allows you to manage and edit many aspects of your application. However, it’s important to understand the impact making changes has on your application, depending on its state.
Developer Rejected
If you need to submit a new binary for your application prior to it being reviewed by the App Store Review Team, you can change the status of your application to Developer Rejected. To do so, log in to iTunes Connect, click on the Manage Your Applications module, then click the Reject Binary button from the application summary view.
Keep in mind that changing the status of your application to Developer Rejected while it is in the review process removes your application from the review queue. The review process will start again from the beginning once you resubmit your binary.
问题的答案是否定的。当应用程序处于审核中状态时，您无法提交新的二进制文件。您只能在自己的应用仍处于等待审核状态时拒绝您自己的应用（开发者拒绝），结果是，当您重新提交时，它会排到审核队列的后面。应用审核中后，您必须等待 Apple 接受或拒绝它。
UPDATE: as per the comment by Autonomy below, it looks like the policy has changed and you can now reject a binary when its status is In Review. I've left my original answer below for reference:
The answer to the question is NO. You cannot submit a new binary when then app is In Review. You can only reject your own app (Developer Rejected) whilst it is still in the Waiting for Review state, with the consequence that when you re-submit it will go to the back of the review queue. Once the app is In Review you have to wait for it to be accepted or rejected by Apple.
发布评论
评论（2）
您可以拒绝第一个二进制文件并上传新的。您在审核队列中的位置将被重置。如果您更担心发布日期而不是稳定性修复，您可以在发布到应用商店后立即提交更新。
App Store 提交提示
You can reject your first binary and upload the new one. Your position in the review queue will be reset. If you are worried about the release date more than your stability fixes you can just submit the update immediately after it is released to the app store.
App Store Submission Tips
更新：根据下面 Autonomy 的评论，政策似乎已更改，当二进制文件的状态为审核中可以拒绝该二进制文件>。我在下面留下了我原来的答案供参考：
问题的答案是否定的。当应用程序处于审核中状态时，您无法提交新的二进制文件。您只能在自己的应用仍处于等待审核状态时拒绝您自己的应用（开发者拒绝），结果是，当您重新提交时，它会排到审核队列的后面。应用审核中后，您必须等待 Apple 接受或拒绝它。
UPDATE: as per the comment by Autonomy below, it looks like the policy has changed and you can now reject a binary when its status is In Review. I've left my original answer below for reference:
The answer to the question is NO. You cannot submit a new binary when then app is In Review. You can only reject your own app (Developer Rejected) whilst it is still in the Waiting for Review state, with the consequence that when you re-submit it will go to the back of the review queue. Once the app is In Review you have to wait for it to be accepted or rejected by Apple.