I worked on a website for about a year in which the entire UI was developed in Laszlo. I've also developed AJAX applications using JS frameworks such as JQuery, Prototype and Scriptaculous.
In my experience, the total effort required is considerably less when using Laszlo, and the class-based object model helps to keep your code better organised than when using JS frameworks. My only complaints about Laszlo were that:
It "breaks the browser" in terms of support for the back/forward/refresh buttons. This problem also exists with AJAX, but most JS libraries seem to have found a workaround.
No support for internationalization, though none of the JS libraries are any better in my experience
Relatively small user base/community compared to competitors such as GWT, JQuery, etc.
All in all, I thought OpenLaszlo was a pretty good solution for creating rich web-based user interfaces, and has a number of very novel features, e.g. ability to deploy on multiple runtimes (Flash, DHTML, etc.) without requiring any code changes.
Also, I should mention that I haven't used it for almost a year, so it's likely that some progress has been made in recent times on the issues I mentioned above.
Update
5 years since I posted this answer, things have changed considerably. In case anyone is in any doubt, don't use Laszlo, the project is completely moribund.
I used openLaszlo to develop a few blog widgets for some friends of mine (about a year ago) and it was easy enough to get something basic working and it looked OK. But if I had to do it again, I would probably use FLEX I think you can make a more polished looking application in a lot less time using Flex than with Laszlo
You definitely can write a flash app quickly with OpenLaszlo. There are a lot of similarities to developing for Silverlight.
One OpenLaszlo lameness is that it uses a lame variation of javascript similar to ActionScript. Takes a little getting used to, if you are used to the latest features.
Also, the final flash file that you end up with is very large (file size) compared to what you can do with other tools.
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我在一个网站上工作了大约一年，整个 UI 都是用 Laszlo 开发的。 我还使用 JQuery、Prototype 和 Scriptaculous 等 JS 框架开发了 AJAX 应用程序。
根据我的经验，使用 Laszlo 所需的总工作量要少得多，并且基于类的对象模型有助于使代码比使用 JS 框架更好地组织。 我对 Laszlo 的唯一抱怨是：
总而言之，我认为 OpenLaszlo 是创建富 Web 的一个非常好的解决方案基于用户界面，并具有许多非常新颖的功能，例如无需更改任何代码即可部署在多个运行时（Flash、DHTML 等）上的能力。
另外，我应该提到，我已经快一年没有使用它了，所以最近在我上面提到的问题上可能已经取得了一些进展。
自从
我发布这个答案五年以来，事情已经发生了很大的变化。 如果有人有任何疑问，请不要使用 Laszlo，该项目已经完全停滞了。
I worked on a website for about a year in which the entire UI was developed in Laszlo. I've also developed AJAX applications using JS frameworks such as JQuery, Prototype and Scriptaculous.
In my experience, the total effort required is considerably less when using Laszlo, and the class-based object model helps to keep your code better organised than when using JS frameworks. My only complaints about Laszlo were that:
All in all, I thought OpenLaszlo was a pretty good solution for creating rich web-based user interfaces, and has a number of very novel features, e.g. ability to deploy on multiple runtimes (Flash, DHTML, etc.) without requiring any code changes.
Also, I should mention that I haven't used it for almost a year, so it's likely that some progress has been made in recent times on the issues I mentioned above.
Update
5 years since I posted this answer, things have changed considerably. In case anyone is in any doubt, don't use Laszlo, the project is completely moribund.
我使用 openLaszlo 为我的一些朋友开发了一些博客小部件（大约一年前），很容易就能获得一些基本的工作，而且看起来还不错。 但如果我必须再做一次，我可能会使用 FLEX 我认为你可以使用 Flex 比使用 Laszlo 花费更少的时间打造出外观更精美的应用程序
I used openLaszlo to develop a few blog widgets for some friends of mine (about a year ago) and it was easy enough to get something basic working and it looked OK. But if I had to do it again, I would probably use FLEX I think you can make a more polished looking application in a lot less time using Flex than with Laszlo
您绝对可以使用 OpenLaszlo 快速编写 Flash 应用程序。 与 Silverlight 开发有很多相似之处。
OpenLaszlo 的一个缺点是它使用了类似于 ActionScript 的 javascript 的蹩脚变体。 如果您习惯了最新功能，则需要一些时间来适应。
此外，与其他工具相比，您最终得到的最终闪存文件非常大（文件大小）。
You definitely can write a flash app quickly with OpenLaszlo. There are a lot of similarities to developing for Silverlight.
One OpenLaszlo lameness is that it uses a lame variation of javascript similar to ActionScript. Takes a little getting used to, if you are used to the latest features.
Also, the final flash file that you end up with is very large (file size) compared to what you can do with other tools.
OpenLaszlo 的优点之一是可以输出 DHTML。 但对我来说，在同一个源文件中混合使用 XML 和 JavaScript 有点令人困惑。
One benefit of OpenLaszlo is the possibility of DHTML output. But for me the mix of XML and JavaScript in the same source file was somewhat confusing.